As a new player to EVE Online it's important that you venture out of High Sec into the other parts of the game. Many new players regard Low and Null Sec as "CERTAIN DEATH!" A place where none can return alive. But that's completely incorrect.
Strangely, there are many cases where Null Sec is the safest space in the game, despite the fact that it is "Lawless."
What really creates danger in EVE is player density and opportunity. Take away either one of those and the danger is minimized.
For example, if you are in a very slow Null Sec pocket of a slow region, there's very little danger. The biggest danger you face is traveling to and from that pocket. This damage can be mitigated with proper piloting and a few warps stabs.
Should you choose to join a larger group that has Sov Null Sec Space, you can use Intel to remove the opportunity from roaming PVPers and gangs.
But don't think this is all Strawberries and Cupcakes... You will still die. Much more so at first than later. But you will die doing this...
And THAT'S OK!
EVE Online is about Risk vs Reward. If you fly a 5 million ISK T1 Frigate out to Null and collect 30-40 Million ISK per hour of loot which you of course store in NPC Stations then just one single hour of successful exploration pays for many ships.
Now the reality is that you won't die very often once you understand the basics, but it's no big deal if you die once a week and lose 5+ million ISK because you made and stored over 200 Million ISK that week and it's all sitting in a station waiting for you to either courier contract out or haul your self in multiple loads (to minimize risk of ganking).
The key to making your first excursion out to Low or Null Sec as safe as possible is proper navigation. Knowing which systems are camped, which regions are too dangerous and which are empty, etc.
That's what I teach in this new video guide aimed at both new Alpha Clones and older Omega's who still haven't gone to Null Sec and seen the extra ISK they can get there.
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Final Tip: When Hauling your loot out, split it into multiple trips, carry it to a non-Jita trade hub like Dodixie or Amarr, and use a ship built for the task. Most gankers sit in and around Jita, as well as in a few systems between Amarr and Jita. Avoid those hot spots and you will increase your survival rate.